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Spontaneous HBsAg seroconversion after severe flare of chronic hepatitis B infection

Akif Altinbaþ, Ilhami Yüksel, Melih Pamukcu, Fuat Ekiz, Ömer Baþar, Osman Yüksel


The results of the acute exacerbations of hepatitis B virus are varied from silent to severe acute hepatitis. HBsAg seroconversion induced by either antiviral drugs or occurred spontaneously, as a targeted end point of HBV infection management is infreaquent. The affect of the severe hepatitic flare on HBsAg seroconversion was reported before, however the predictive markers of HBsAg seroconversion are not clear yet. The reasons of the spontaneously HBV re-activations, or its usual results are not known well. We, herein reported a case, with the high serum HBV DNA titer during an acute spontaneously induced severe exacerbation of HBV infection which spontaneously resulted in total HBV recovery.

Key words. Spontaneous HBsAg seroconversion, Chronic hepatitis B infection, Spontaneous HBV recovery

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The Official Journal of the Mexican Association of Hepatology, the Latin-American Association for the Study of the Liver and the Canadian Association for the Study of the Liver

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