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Rescue Therapy for Genotype-3 DAA Non-responders, Almost all Done

Susana Llerena, Joaquín Cabezas, Antonio Cuadrado, Jose Manuel Olmos, Marta González, Federico García, Carmen Cobo, Javier Crespo

Abstract

Nowadays, the retreatment of patients with Hepatitis C virus (HCV) genotype 3 (GT3) especially cirrhotic, who have already been treated with regimens containing a NS5A inhibitor represents a challenge. Use a novel retreatment option for patients with a difficult approach. We present three case reports of retreatment with a new combination of Direct-acting antivirals (DAAs), Sofosbuvir, Elbasvir/ Grazoprevir in patients with GT3 with a previous failure with Sofosbuvir/Ledipasvir. All the cases achieved sustained virologic response (SVR) at week +12 without adverse effects. In our experience, this combo may represent an effective and safe option for these patients.

Key words. Hepatitis C virus, Treatment failure, Genotype 3, Sofosbuvir, Grazoprevir + Elbasvir

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The Official Journal of the Mexican Association of Hepatology, the Latin-American Association for the Study of the Liver and the Canadian Association for the Study of the Liver

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