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Effects of Age on Treatment of Chronic Hepatitis C with Direct Acting Antivirals

Alexandre Pariente, Jean-Pierre Arpurt, Andre-Jean Remy, Isabelle Rosa-Hezode, Xavier Causse, Frederic Heluwaert, Gilles Macaigne, Jean Henrion, Christophe Renou, Matthieu Schnee, Hatem Salloum, Severine Hommel, Christophe Pilette, Ramuntxo Arotcarena, Georges Barjonet, Hortensia Lison, Francois Bourhis, Vincent Jouannaud, Arnaud Pauwels, Yann Le-Bricquir, Edmond Geagea, Bertrand Condat, Marie-Pierre Ripault, David Zanditenas, Stephanie de Montigny-Lenhardt, Helene Labadie, Bertrand Tissot, Eric Maringe, Jean-Francois Cadranel, Herve Hagege, Bruno Lesgourgues

Abstract

Introduction and aim. Data on the efficacy and tolerance of interferon-free treatment in chronic hepatitis C (CHC) in elderly patients are limited in phase II-III trials. Material and methods. A prospective cohort of adult patients with CHC treated in French general hospitals. Results. Data from 1,123 patients, distributed into four age groups, were analyzed. Of these, 278 were ≥ 64 years old (fourth quartile) and 133 were ≥ 73 years old (tenth decile). Elderly patients weighed less, were more frequently treatment-experienced women infected with genotype 1b or 2, while they less frequently had genotype 3 or HIV coinfection, but had more frequent comorbidities and drug consumption. Half of the patients had cirrhosis, whatever their ages. The main treatment regimens were sofosbuvir/ledipasvir (37.8%), sofosbuvir/daclatasvir (31.8%), sofosbuvir/simeprevir (16.9%), sofosbuvir/ribavirin (7.8%); ribavirin was given to 24% of patients. The overall sustained virological response (SVR) rate was 91.0 % (95% CI: 89.2- 92.5%) with no difference according to age. Logistic regression of the independent predictors of SVR were albumin, hepatocellular carcinoma and treatment regimen, but not age. The rate of severe adverse events (66 in 59/1062 [5.6%] patients) tended to be greater in patients older than 64 years of age (21/261, 8.1%), but the only independent predictors of SAE by logistic regression were cirrhosis and baseline hemoglobin. Patient-reported overall tolerance was excellent in all age groups, and patient-reported fatigue decreased during and after treatment, independent of age. Conclusions. The high efficacy and tolerance of interferonfree regimens is confirmed in elderly patients in real-life conditions.

Key words. Sustained Virological Response, Hospitals, General, Comorbidities, Prospective, Patients-reported outcomes

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The Official Journal of the Mexican Association of Hepatology, the Latin-American Association for the Study of the Liver and the Canadian Association for the Study of the Liver

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