Giulio Marchesini, Francesca Marchignoli, Salvatore Petta
Healthy controls are subjects without the disease being studied but may have other conditions indirectly affecting outcome. In the present epidemics of obesity a few subjects with undiagnosed nonalcoholic fatty liver disease enter clinical studies as controls, producing biased results. Stricter selection criteria should be considered to prevent this risk.
Key words. Clinical trials., Control group., Liver Enzymes., NAFLD., Obesity.