ANNALS OF HEPATOLOGY (ISSN 1665-2681) is an international
open access journal published bi-monthly and is funded by
Medica Sur Clinic & Foundation, Mexico City, Mexico.
ANNALS OF HEPATOLOGY, the official journal of the Mexican
Association of Hepatology (AMH), the Latin-American Association
for the Study of the Liver (ALEH) and the Canadian
Association for the Study of the Liver (CASL) publishes original papers,
concise reviews, letters to the Editor, invited editorials, opinions
and viewpoints in the field of Hepatology.
ANNALS OF HEPATOLOGY'S main topics are alcoholic liver
disease, viral hepatitis (HAV, HBV, HCV, HDV, HEV), NAFLD/
NASH, genetic liver diseases, autoimmune hepatitis, drug-induced
liver injury and biliary diseases. The journal's aim is to publish articles
focused on basic, clinic care and translational research that
seeks to prevent rather than treating the complications of end-stage
liver disease. We encourage the submission of articles that provide
new insights in emerging topics in the field of Hepatology such as:
• Advances in early molecular and clinical diagnosis of liver disease.
• Genome-based nutrition for healthier liver function and in liver
• Regionalized and individualized medicine tailored by population.
• Genetic and environmental factor interactions: genes-alcohol,
genes-NASH, genes-viral hepatitis.
• Strategies preventing or halting the progression of chronic injury
by any etiological agent.
• Treatment by either medication, lifestyle interventions, liver
transplantation, or gene therapy.
Authors interested in contributing reviews or case reports are requested
to first contact the Editor or one of the Associate Editors
with an outline of the proposed article.
Regular case reports will not be longer accepted even if they
provide interesting clinical information. Case reports will only be
accepted if they represent an outstanding contribution to the etiology,
pathogenesis or treatment of a specific liver disorder. Correspondence
may be subjected to peer review and undergo editing for
clarity and brevity.
The journal publishes only in English. Authors lacking facility
with English syntax should seek the appropriate editorial assistance
prior to submitting their manuscript. Material requiring major editorial
work will be returned without review.
Authors must submit a complete electronic copy of the manuscript,
tables, figures, author and copyright agreement using the online
submission system that can be accessed from our web page:
www.annalsofhepatology.com. Exceptionally, manuscripts can
be send to the e-mail address below. All manuscripts should be prepared
as specified further down.
The journal uses anonymous peer review in evaluating manuscripts
for publication. Manuscripts the Editors think are incomplete
or unlikely to be accepted will be returned to the authors as
an Early Reject without a full peer review. The Editors allow a single
resubmission only after the initial disposition, which should be
received within 4 months from the time of receipt of the initial disposition
letter. A manuscript requiring more than a single revision
or returned beyond 4 months will be considered a new submission.
All submitted materials remain in the Editorial Office.
Copyright of all material published in ANNALS OF HEPATOLOGY
is vested in Fundación Clínica Médica Sur. Copyright
Assignment form (which follows these guidelines) signed by all authors
must accompany all manuscripts. Statements and opinions expressed
in the articles and communications in ANNALS OF
HEPATOLOGY are those of the author(s) and not necessarily
those of the Editor(s) or publisher, and the Editor(s) and publisher
disclaim any responsibility or liability for such material. Neither the
Editor(s) nor the publisher guarantees, warrants, or endorses any
product or service advertised in the journal, nor do they guarantee
any claim made by the manufacturer of such product or service.
Any material that could constitute prior or concurrent publication
of similar data by any one of the authors should be submitted
with the manuscript. Such material includes symposium proceedings,
book chapters, invited papers, and the like. Indicate explicitly
in your cover letter what is truly new in the present work compared
to work already published in the field.
Authors may suggest the names of reviewers whose expertise
qualifies them to review the work. Any reviewers the authors wish to
exclude may be listed along with the reason for exclusion. While all
suggestions will be considered, the final choice of reviewers rests
with the Editor or responsible Associate Editor. Please provide information
about the individual contribution of each author and
name the author who is responsible for the integrity of the work as
It is assumed that the corresponding author speaks for his or her
coauthors and certifies that all listed authors participated meaningfully
in the study and that they have seen and approved the final
manuscript. The letter should describe any commercial affiliation
or consultancy of an author that could be construed as a conflict of
interest with respect to the submitted data. If the Editor finds that
such activities raise the appearance of a conflict, he may recommend
disclosure in a footnote. Otherwise, the information will remain
TYPES OF MANUSCRIPTS
• Concise reviews.
• Original articles.
• Case reports.
• Milestones in Hepatology
• Education and Training in Hepatology
Editorials are commentaries written by the editors or by their invitation
that focus on 1 or a series of articles in the ANNALS OF HEPATOLOGY or on topics of special importance to our readership.
Maximum specifications: 1,200 to 1,500 words (excluding title,
byline, and references), and no more than 1 table and/or figure with
reduction in word count; 10 to 15 references; up to 3 authors.
Essays representing opinions, presenting hypotheses, or considering
controversial issues in all areas of hepatology [See above:
Sometimes solicited by editors, typically peer reviewed].
• Abstract yes, see above.
• Text: 1,000 words maximum (excluding references).
• References: 10 or fewer bibliographic references.
• Tables/Figures: typically no tables or figures but occasional exception
at the editors' discretion.
These papers may address virtually any important topic in hepatology
and generally are not linked to a specific article. Viewpoints
should be well focused, scholarly, and clearly presented and must
have no more than 3 authors. The text should include the full name,
academic degrees, and no more than 2 institutional affiliations for
each author. Maximum length: up to 1,200 words of text -or 1,000
words of text with 1 small table or figure- and no more than 7 references.
Addtionally, unstructured short abstract with maximum 50
words. Submissions not meeting these guidelines will not be considered.
Viewpoints are commonly invited but unsolicited submissions
are also welcome. They all undergo the usual peer review of ANNALS
The maximum length for Concise reviews of both basic and
clinical topics is should be no longer than 3,500 words and the reference
list need not be exhaustive.
The maximum length of manuscripts that describe an original research
is 4,000 words (excluding references) and include no more than
50 references. Manuscripts that are redundant or contain extraneous
material will be returned for shortening, even if otherwise acceptable.
Image in Hepatology
Image in Hepatology section means a figure(s) that summarizes
current knowledge about a particular subject within the hepatology
field, and the first part should contain a very brief clinical introduction
to a case followed by an image and the discussion. The limit is
It is expected that submitted case reports will include a detailed
analysis of the case and a review of the available literature. Only
those case reports which are truly original and are likely to significantly
influence medical practice are likely to be considered for
publication. Others may be considered for publication in an abbreviated
form as a letter to the editor.
Letters to the editor which comment on articles recently published
in The ANNALS OF HEPATOLOGY are invited. Brief case
reports or new findings may also be submitted and include a single
supporting illustration. Letters should be double-spaced and no
longer than 500 words (including references) and include no more
than 10 references and one figure.
Milestones in Hepatology
Invited or proposed articles related to historical commentaries in
regards to the biography and contributions of outstanding clinicians,
researchers or mentors in the field of Hepatology with emphasis in
their impact in clinical care, teaching and research. Chronological
timelines in regards to the topics or trends in hepatology can also be
considered. Maximum specifications: 1,500-2,000 words (excluding
title, byline, and references), and no more than 1 table and/or figure
(image, 300 dpi, jpg or tif file); 10 or fewer bibliographic references.
Education and Training in Hepatology
Relates to education and practice articles that provide novel
training strategies, management flow charts or qualitative research
in medical education and training with a meaningful impact on the
prevention, management or treatment of liver disease. Maximum
specifications: 3,000 words (excluding title, byline, and references),
and up to 2 illustrations (table and/or figure); 25 or fewer bibliographic
Content will consist of notes and information in regards to yearround
academic and scientific activities of the respective official associations.
This section will be open for announcements of new
presidencies, clinical practice guidelines or consensus statements.
One page and with no more than 1 table and/or figure; 5 or fewer
ORGANIZATION OF THE MANUSCRIPT
Manuscripts describing original research should contain (in this
order) a title page, a footnote page, an abstract, an introductory
statement (without heading), a description of experimental procedures
or methods, the results, a discussion and, on separate pages, a
list of references, figure legends, and tables. Authors have the option
of combining the results and discussion and are encouraged to do
so for short manuscripts. Abstract should be divided into the following
sections: Introduction and aim, Materials and methods, Results,
and Conclusion. Text: divided into the following sections:
Introduction, Materials and methods, Results, and Discussion. Abstracts
for case reports should not be divided into sections.
All manuscripts should be double-spaced throughout, including
the footnote page, list of references, figure legends, and tables. All
pages must be numbered in the upper right-hand corner, starting
with the title page.
Provide a concise title of not more than 100 characters, not including
spaces between words. If possible, with only the first letter
of the first word capitalized. In the case of work with experimental
animals, indicate the species used. List the full names of the
author(s). Authors' last names-listed separately for PubMed indexing.
Names of authors should be arranged as follows: Roberto J.
Carvalho-Filho. First name, middle initials if required, and surname
must joined with a hyphen. Author names must be placed next to
each other. Indicate the institutional affiliation. In a multi-authored
work involving more than a single institution, indicate individual affiliation
by means of a superscript Arabic number. Any change in authorship after submission must be approved in writing by all authors.
Indicate a change of address similarly. Corresponding author.
Provide the academic degrees, name, mailing address, telephone
number, and e-mail address. It's not possible to add more than one
Provide a list of up to 5 key words that do not appear in the title
itself. Manuscripts will not be accepted without a full title page.
List footnotes to the title page. Provide the contact information
for the author to whom proofs should be sent (name, address,
telephone number, fax number, and e-mail address). List
abbreviations used with the expansions in the order of their mention
in the paper. Finally, list grants and other financial support
on this page.
Abstract should be divided into the following sections: Introduction
and aim, Materials and methods, Results, and Conclusion. Abstracts
for case reports should not be divided into sections. The
total length not exceed 250 words.
Provide the minimum background information that will orient
the general reader. Do not engage in a literature review.
Provide a level of detail such that another investigator could repeat
the work; for methods that are used without significant modification,
citation of the original work will suffice.
• Human subjects.
For reports of research using human subjects,
provide assurance that (a) informed consent in writing was
obtained from each patient and (b) the study protocol conformed
to the ethical guide lines of the 1975.
Declaration of Helsinki as reflected in a priori approval by the
appropriate institutional review committee. Refer to individual
patients by number, not by initials.
• Animal experimentation.
In studies involving animal experimentation,
provide assurance that all animals received humane
care according to the criteria outlined in the "Guide for the
Care and Use of Laboratory Animals" prepared by the National
Academy of Sciences and published by the National Institutes
of Health (NIH publication 86-23 revised 1985).
Genetic sequence data. In papers reporting a novel DNA or
amino acid sequence, verify that the data have been or will be
submitted either to GenBank or EMBL, and provide the accession
number. This information need not accompany the initially
submitted manuscript but must be available for inclusion in the
final publication. Accession numbers appear as footnotes to the
text or in the relevant figure legend. It is understood that authors
publishing in ANNALS OF HEPATOLOGY will make
cloned DNA, hybridomas, mutant animals, and other resources
available to qualified investigators.
Include the names and locations (city and state or country) of
manufacturers when mentioning proprietary drugs, tools, instruments,
Identify and provide references for the statistical
methods used. The legends of figures and tables should specify
the number of observations and whether estimates of variance
are SD or SE.
RESULTS AND DISCUSSION
Present the major findings of the study in graphic form if practicable.
Do not illustrate minor details if their message is conveyed
adequately by simple descriptive text. Mention all tables and figures.
In the discussion, concisely present the implications of the new
findings for the field as a whole, minimizing reiteration of the results,
avoiding repetition of material in the introduction, and keeping
a close focus on the specific topic of the paper.
Acknowledge personal assistance and providers of special reagents.
Note that grant and other financial support is listed on the
footnote page, not here.
Number references in the order cited as Arabic numerals in parentheses
on the line. Only literature that is published or in press
(with the name of the publication known) may be numbered and
listed; abstracts and letters to the editor may be cited, but they must
be less than 3 years old and identified as such. Refer to only in the
text, in parentheses, other material (manuscript submitted, unpublished
data, personal communication, and the like) as in the following
example: (Chercheur X, unpublished data). If the owner of the
unpublished data or personal communication is not an author of
the manuscript under review, a signed statement is required verifying
the accuracy of the attributed information and agreement to its
publication. Do not use Endnote or other word processing tools
that may embed references in code. Type reference numbers in parentheses
within the text and type out the reference list as normal
text at the end of the manuscript.
Use Index Medicus as the style guide for references and other
journal abbreviations. The issue number (immediately following the
volume number in parentheses) should not appear in the reference,
names of journals should be written in italics and "et al." should be
used only after the seventh author has been listed.
ARTICLES IN JOURNALS
1. Miquel JF, Covarrubias C, Villaroel L, Mingrone G, Greco
AV, Puglielli L, Carvallo P, et al. Genetic epidemiology of cholesterol
cholelithiasis among Chilean Hispanics, Amerindians, and
Maoris. Gastroenterology 1998; 115: 937-46.
2. Watson JD. The Double Helix. New York: Atheneum; 1968,
3. Hofmann AF. The enterohepatic circulation of bile acids in
health and disease. In: Sleisinger MH, Fordtran JS (eds.). Gastrointestinal
Disease. Volume 1. 5th ed. Philadelphia: Saunders, 1993, p.
Direct quotations, tables, or illustrations taken from copyrighted
material must be accompanied by written permission for their use
from the publisher and the original author. A standard permission
request form is included in this section. The permission is presented
as a footnote or addition to the legend and must provide complete information as to source. Photographs of identifiable persons must
be accompanied by a signed release that indicates informed consent.
Standard abbreviations not requiring definition can be found in
the American Medical Association Manual of Style. Do not abbreviate
otherwise unless a term is used more than five times in the
manuscript. In this case, the abbreviation should be spelled out, in
parentheses, in its first use in the text and also listed on the footnote
page (see previous page). Abbreviations used in figures or tables
should be defined in the legend. Express temperatures as degrees
Celsius and other measurements in SI units.
Use generic names. The proprietary name may be mentioned in
parentheses with the name and location (city and state or country)
of the manufacturer.
Prepare tables on individual pages, double spaced and numbered
consecutively with Arabic numerals in the order of their appearance
in the text. Do not duplicate material presented in a
Number figures with Arabic numerals in the order mentioned in
the text. Provide a title (this should not appear on the figure itself)
and sufficient explanation to render the figure intelligible without
reference to the text. Explain all abbreviations and symbols. For any
copyrighted material, indicate that permission has been obtained
(see Permissions, above).
Images, graphics, tables, etc. should be provided, ideally, as files
from the program in which they were made, indicating which program
it was. Otherwise send them as separate jpg or tiff files with a
resolution of 300 dpi (dots per inch).
Cover photograph. Authors with accepted manuscripts (or accepted
pending minor revision) may submit artwork for consideration
for the cover. The material may be different from the figures
used in the article but should represent its content. Single slides or
color photographs are preferred, and multiple examples may be
submitted. Individual photographs should be accompanied by a
four- to five word caption and a two-sentence legend. Authors are
not charged for a cover photograph.
Most word-processing formats are acceptable (Microsoft Word,
Word Perfect); Microsoft Word is preferred. If the program used is
non-standard, the material should be provide also in text format on
a separate disk, marked as "a text file".
Typographical formatting (column widths, type style, etc.) will
be handled by the publisher. Do not use this type of formatting. Editorial
formatting (use of italics, superscripts, Greek letter, etc.) may
be included in the disk file. The coding scheme for such elements
must be consistent throughout the file.
• Text Style. Type text flush left (do not indent paragraphs). Use
two carriage returns at the end of a paragraph to separate it
from the one that follows. Enter only one space between words
and after sentences. Use 1 carriage return ("hard return") only
after a heading and use 2 carriage returns at the end of a paragraph.
Allow line breaks within a paragraph to be determined
automatically by the word-processing program. If it is necessary
to force the end of a line within a paragraph, use the program's
"soft return" feature. Do not use the program's indenting or
margin-setting features (These will be added during typesetting).
COPYRIGHT PERMISSION REQUEST FORM
Dear Permission Editor/Author:
I am preparing for publication an article entitled:
to be published in.
I hereby request your permission for the nonexclusive right to
reprint the following material:
Title of article or book:
Year of publication:
Journal, volume, and issue (if applicable):
Material to be reproduced:
Page number(s) it appeared on:
Permission is sought to reprint the above material in all
forms and media now and hereafter known, in all languages,
throughout the world and to license such rights to others.
I/We hereby grant permission to reprint the material(s) as
Copyright assignment, authorship responsibility, financial disclosure,
and institutional review board/animal care committee
• Copyright assignment.
In consideration of the Fundación
Clínica Médica Sur (FCMS) taking action to review and edit
my submission, the undersigned authors, jointly and severally,
hereby transfer, convey, and assign all right, title, and interest
therein, including any and all copyrights in all forms and media
now or hereafter known, to the FCMS. The authors retain the
nonexclusive right to use all or part of the Article in future
works of their own in a noncompeting way, provided proper
copyright credit is given to the Foundation.
Should the FCMS not publish the aforesaid submission, the
FCMS agrees to release its rights therein (Note: material prepared
by employees of the federal government in their official
duties may not be copyrightable). No guarantee is made that
the Article will be published.
• Authorship responsibility.
I, the undersigned author, certify
that I have participated sufficiently in the intellectual content,
the analysis of data, if applicable, and the writing of the Article,
to take public responsibility for it. I have reviewed the final version
of the Article, believe it represents valid work, and approve
it for publication. As an author of this Article, I certify that
none of the material in the manuscript has been published previously, is included in another manuscript, or is currently under
consideration for publication elsewhere. I also certify that the
Article has not been accepted for publication elsewhere, nor
have I assigned any right or interest in the Article to any third
• Financial disclosure.
I, the undersigned author, certify that I
have no commercial associations (e.g., consultancies, stock
ownership, equity interests, patent-licensing arrangements) that
might pose a conflict of interest in connection with the submitted
Article, except as disclosed on a separate attachment. All
funding sources supporting the work and all institutional or
corporate affiliations of mine are acknowledged in a footnote.
• Institutional Review Board/Animal Care Committee Approval.
I, the undersigned author, certify that my institution has
approved the protocol for any investigation involving humans
or animals and that all experimentation was conducted in conformity
with ethical and humane principles of research.
Each author must sign and date this statement. In the case of a
work made for hire, the employer must also sign.
Employer signature (required for works made for hire):
Address manuscripts to:
Arturo Panduro, M.D., Ph.D., FAASLD.
Annals of Hepatology
Department of Molecular Biology in Medicine,
Civil Hospital of Guadalajara,
"Fray Antonio Alcaldes", and Health
Sciences Center, University of Guadalajara, Guadalajara,
Hospital No. 278, Col. El Retiro, 44280,
Guadalajara, Jalisco, Mexico.
Tel.: (52) 3336147743.
E-mail: email@example.com, firstname.lastname@example.org
• A completed checklist must accompany the manuscript. Failure
to comply with directions may result in delay in review of your
• Eliminate nonstandard abbreviations in titles.
• Supply full author names.
• Indicate institutional affiliations clearly.
• Identify corresponding author and supply accurate address, telephone
number, fax number, and e-mail address, if available.
• Include written permission for any borrowed or modified figures
or tables from the author and copyright holder.
• Make sure abstract does not exceed 250 words.
• Do not cite references, tables, or figures in the abstract.
• Supply statement in the "Materials and Methods" section regarding
consent of human subjects and approval by ethics committee.
If animals are used in experiments, use and indicate
National Institutes of Health guidelines, U.S.A.
• Make sure text is clear, easy to follow, and legible.
• Make sure English is grammatically correct and idiomatic.
• Supply full manufacturer names and addresses (city and state or
country) for all brand name products used in experiments.
• Supply references in the style of the journal: authors (first seven
names before the use of et al.), title, journal, year, volume, and
• Punctuation should follow ANNALS OF HEPATOLOGY
• Check that references are accurate and cited in the text in numerical
• Supply tables on separate pages; they should read vertically
when possible and should have headings for each column.
• Cite tables in the text in numerical order. Use arabic numerals,
not roman numerals
• Do not cite materials submitted but not yet accepted for publication
as references. Instead, cite in text.
• Make sure figures are of good quality.
• Cite figures in the text in numerical order.
• Include author's checklist and signed copyright assignment
form with manuscript submission.